Mundo EPOC

¿Qué hay de nuevo en la EPOC?

Referencias Bibliográficas sobre EPOC 2012

La EPOC es una enfermedad en la cual se avanza continuamente en su conocimiento, por lo que todos los meses aparecen numerosas publicaciones al respecto. Para el clínico es difícil mantenerse al día dada la gran cantidad de información y el poco tiempo del que habitualmente dispone para realizar una buena selección de la misma. A continuación enumeramos una selección de artículos publicados desde enero de 2007 en relación con distintos aspectos de la EPOC. Cada referencia está enlazada para la búsqueda de la referencia completa en Medline.

Diagnóstico, pronóstico y seguimiento de la EPOC

  1. Chandra D, Wise RA, Kulkarni HS, Benzo RP, Criner G, Make B, Slivka WA, Ries AL, Reilly JJ, Martinez FJ, Sciurba FC; NETT Research Group.
    Optimizing the 6-min walk test as a measure of exercise capacity in COPD.
    Chest. 2012 Dec;142(6):1545-52. doi: 10.1378/chest.11-2702. PubMed PMID: 23364913; PubMed Central PMCID: PMC3515028.


  2. Cerveri I, Corsico AG, Grosso A, Albicini F, Ronzoni V, Tripon B, Imberti F, Galasso T, Klersy C, Luisetti M, Pistolesi M.
    The Rapid FEV(1) Decline in Chronic Obstructive Pulmonary Disease Is Associated with Predominant Emphysema: A Longitudinal Study.
    COPD. 2012 Dec 28. [Epub ahead of print] PubMed PMID: 23272662.


  3. Carlsen J, Hasseriis Andersen K, Boesgaard S, Iversen M, Steinbrüchel D, Bøgelund Andersen C.
    Pulmonary arterial lesions in explanted lungs after transplantation correlate with severity of pulmonary hypertension in chronic obstructive pulmonary disease.
    J Heart Lung Transplant. 2012 Dec 19. doi:pii: S1053-2498(12)01409-X. 10.1016/j.healun.2012.11.014. [Epub ahead of print] PubMed PMID: 23265910.


  4. Takahashi M, Yamada G, Koba H, Takahashi H.
    Classification of Centrilobular Emphysema Based on CT-Pathologic Correlations.
    Open Respir Med J. 2012;6:155-9. doi: 10.2174/1874306401206010155. Epub 2012 Dec 14. PubMed PMID: 23264837; PubMed Central PMCID: PMC3527991.


  5. Eppert BL, Wortham BW, Flury JL, Borchers MT.
    Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease.
    J Immunol. 2013 Feb 1;190(3):1331-40. doi: 10.4049/jimmunol.1202442. Epub 2012 Dec 21. PubMed PMID: 23264660; PubMed Central PMCID: PMC3552128.


  6. Fan L, Xia Y, Guan Y, Yu H, Zhang TF, Liu SY, Li B.
    Capability of differentiating smokers with normal pulmonary function from COPD patients: a comparison of CT pulmonary volume analysis and MR perfusion imaging.
    Eur Radiol. 2012 Dec 21. [Epub ahead of print] PubMed PMID: 23263604.


  7. Tsuchida T, Matsuse H, Nishino T, Kawano T, Fukushima C, Hayashi T, Kohno S.
    Pathologically confirmed, early-onset, severe chronic obstructive pulmonary disease.
    Intern Med. 2012;51(24):3411-4. Epub 2012 Dec 15. PubMed PMID: 23257530.


  8. Saunders DN, Tindall EA, Shearer RF, Roberson J, Decker A, Wilson JA, Hayes VM.
    A novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency.
    PLoS One. 2012;7(12):e51762. doi: 10.1371/journal.pone.0051762. Epub 2012 Dec 12. PubMed PMID: 23251618; PubMed Central PMCID: PMC3520848.


  9. Stoll P, Wuertemberger U, Bratke K, Zingler C, Virchow JC, Lommatzsch M.
    Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD.
    Respir Res. 2012 Dec 17;13:116. doi: 10.1186/1465-9921-13-116. PubMed PMID: 23245944; PubMed Central PMCID: PMC3561140.


  10. Kirby M, Svenningsen S, Kanhere N, Owrangi A, Wheatley A, Coxson HO, Santyr GE, Paterson NA, McCormack DG, Parraga G.
    Pulmonary Ventilation Visualized using Hyperpolarized Helium-3 and Xenon-129 Magnetic Resonance Imaging: Differences in COPD and Relationship to Emphysema.
    J Appl Physiol. 2012 Dec 13. [Epub ahead of print] PubMed PMID: 23239874.

  11. Burgel PR, Paillasseur JL, Peene B, Dusser D, Roche N, Coolen J, Troosters T, Decramer M, Janssens W.
    Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
    PLoS One. 2012;7(12):e51048. doi: 10.1371/journal.pone.0051048. Epub 2012 Dec 7. PubMed PMID: 23236428; PubMed Central PMCID: PMC3517611.


  12. Kim C, Seo JB, Lee SM, Lee JS, Huh JW, Lee JH, Ra SW, Lee JH, Kim EK, Kim TH, Kim WJ, Lee SM, Lee SY, Lim SY, Shin TR, Yoon HI, Sheen SS, Oh YM, Park YB, Lee SD.
    Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD.
    Respiration. 2012 Dec 11. [Epub ahead of print] PubMed PMID: 23235126.


  13. Piras B, Ferrarotti I, Lara B, Martinez MT, Bustamante A, Ottaviani S, Pirina P, Luisetti M, Miravitlles M.
    Clinical phenotypes of Italian and Spanish patients with Alpha-1-antitrypsin deficiency.
    Eur Respir J. 2012 Dec 6. [Epub ahead of print] PubMed PMID: 23222880.


  14. Kim SS, Seo JB, Lee HY, Nevrekar DV, Forssen AV, Crapo JD, Schroeder JD, Lynch DA.
    Chronic Obstructive Pulmonary Disease: Lobe-based Visual Assessment of Volumetric CT by Using Standard Images--Comparison with Quantitative CT and Pulmonary Function Test in the COPDGene Study.
    Radiology. 2013 Feb;266(2):626-635. Epub 2012 Dec 6. PubMed PMID: 23220894.


  15. Adir Y, Shachner R, Amir O, Humbert M.
    Severe pulmonary hypertension associated with emphysema: a new phenotype?
    Chest. 2012 Dec;142(6):1654-8. doi: 10.1378/chest.11-2816. PubMed PMID: 23208339.


  16. Jones HA, Soler N.
    Quantification of pulmonary inflammation by positron emission tomography in chronic obstructive pulmonary disease: a new horizon in the era of biomarkers?
    Am J Respir Crit Care Med. 2012 Dec 1;186(11):1071-3. doi: 10.1164/rccm.201208-1377ED. PubMed PMID: 23204371.


  17. Sethi S, Mahler DA, Marcus P, Owen CA, Yawn B, Rennard S.
    Inflammation in COPD: implications for management.
    Am J Med. 2012 Dec;125(12):1162-70. doi: 10.1016/j.amjmed.2012.06.024. Review. PubMed PMID: 23164484.


  18. Warburton D, Shi W, Xu B.
    TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?
    Am J Physiol Lung Cell Mol Physiol. 2013 Jan;304(2):L83-5. doi: 10.1152/ajplung.00258.2012. Epub 2012 Nov 16. PubMed PMID: 23161884.


  19. Inghammar M, Engström G, Löfdahl CG, Egesten A.
    Validation of a COPD diagnosis from the Swedish Inpatient Registry.
    Scand J Public Health. 2012 Dec;40(8):773-6. doi: 10.1177/1403494812463172. Epub 2012 Oct 19. PubMed PMID: 23085721.


  20. Mallia P, Footitt J, Sotero R, Jepson A, Contoli M, Trujillo-Torralbo MB, Kebadze T, Aniscenko J, Oleszkiewicz G, Gray K, Message SD, Ito K, Barnes PJ, Adcock IM, Papi A, Stanciu LA, Elkin SL, Kon OM, Johnson M, Johnston SL.
    Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease.
    Am J Respir Crit Care Med. 2012 Dec 1;186(11):1117-24. doi: 10.1164/rccm.201205-0806OC. Epub 2012 Sep 28. PubMed PMID: 23024024; PubMed Central PMCID: PMC3530206.


  21. Rezende Gonçalves J, Corso Pereira M, Figueiras Pedreira De Cerqueira EM, Oliveira Magro D, Mello Moreira M, Paschoal IA.
    Severe obstructive disease: Similarities and differences between smoker and non-smoker patients with COPD and/or bronchiectasis.
    Rev Port Pneumol. 2013 Jan;19(1):13-8. doi: 10.1016/j.rppneu.2012.05.003. Epub 2012 Sep 25. English, Portuguese. PubMed PMID: 23017504.


  22. Lanzetti M, da Costa CA, Nesi RT, Barroso MV, Martins V, Victoni T, Lagente V, Pires KM, e Silva PM, Resende AC, Porto LC, Benjamim CF, Valença SS.
    Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.
    Free Radic Biol Med. 2012 Dec 1;53(11):1993-2001. doi: 10.1016/j.freeradbiomed.2012.09.015. Epub 2012 Sep 19. PubMed PMID: 23000243.


  23. Koyama H, Ohno Y, Nishio M, Takenaka D, Yoshikawa T, Matsumoto S, Nishimura Y, Sugimura K.
    Three-dimensional airway lumen volumetry: comparison with bronchial wall area and parenchymal densitometry in assessment of airway obstruction in pulmonary emphysema.
    Br J Radiol. 2012 Dec;85(1020):1525-32. doi: 10.1259/bjr/22602417. Epub 2012 Aug 29. PubMed PMID: 22932062.


  24. Garcha DS, Thurston SJ, Patel AR, Mackay AJ, Goldring JJ, Donaldson GC, McHugh TD, Wedzicha JA.
    Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD.
    Thorax. 2012 Dec;67(12):1075-80. doi: 10.1136/thoraxjnl-2012-201924. Epub 2012 Aug 3. PubMed PMID: 22863758.


  25. Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H.
    Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility.
    Thorax. 2012 Dec;67(12):1067-74. doi: 10.1136/thoraxjnl-2011-201395. Epub 2012 Jul 27. PubMed PMID: 22843558.


  26. Subramanian DR, Jenkins L, Edgar R, Quraishi N, Stockley RA, Parr DG.
    Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission tomography.
    Am J Respir Crit Care Med. 2012 Dec 1;186(11):1125-32. doi: 10.1164/rccm.201201-0051OC. Epub 2012 Jul 26. PubMed PMID: 22837375.


  27. Nilius G, Franke KJ, Domanski U, Rühle KH, Kirkness JP, Schneider H.
    Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure.
    Adv Exp Med Biol. 2013;755:27-34. PubMed PMID: 22826046.


  28. Chmielowicz-Frontczak B, Panaszek B, Obojski A.
    Hospital management of patients with exacerbation of severe chronic obstructive pulmonary disease.
    Adv Exp Med Biol. 2013;755:11-7. PubMed PMID: 22826044.


  29. Koenigkam-Santos M, Puderbach M, Gompelmann D, Eberhardt R, Herth F, Kauczor HU, Heussel CP.
    Incomplete fissures in severe emphysematous patients evaluated with MDCT: incidence and interobserver agreement among radiologists and pneumologists.
    Eur J Radiol. 2012 Dec;81(12):4161-6. doi: 10.1016/j.ejrad.2012.06.006. Epub 2012 Jul 6. PubMed PMID: 22770581.


  30. Mohamed Hoesein FA, Zanen P, Boezen HM, Groen HJ, van Ginneken B, de Jong PA, Postma DS, Lammers JW.
    Lung function decline in male heavy smokers relates to baseline airflow obstruction severity.
    Chest. 2012 Dec;142(6):1530-8. PubMed PMID: 22722231.


  31. Sant'Anna T, Escobar VC, Fontana AD, Camillo CA, Hernandes NA, Pitta F.
    Evaluation of a new motion sensor in patients with chronic obstructive pulmonary disease.
    Arch Phys Med Rehabil. 2012 Dec;93(12):2319-25. doi: 10.1016/j.apmr.2012.05.027. Epub 2012 Jun 15. PubMed PMID: 22705466.


  32. Gelb AF, Barnes PJ, George SC, Ricciardolo FL, DiMaria G, Zamel N.
    Review of exhaled nitric oxide in chronic obstructive pulmonary disease.
    J Breath Res. 2012 Dec;6(4):047101. doi: 10.1088/1752-7155/6/4/047101. Epub 2012 Jun 7. PubMed PMID: 22677633.


  33. Steiner MC, Roubenoff R, Tal-Singer R, Polkey MI.
    Prospects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational review.
    Thorax. 2012 Dec;67(12):1102-9. doi: 10.1136/thoraxjnl-2012-201765. Epub 2012 May 5. Review. PubMed PMID: 22561528.



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  34. Vijayasaratha K, Stockley RA
    Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD
    Int J Chron Obstruct Pulmon Dis. 2012;7:789-96. doi: 10.2147/COPD.S31797. Epub 2012 Nov 27.PubMed Central PMCID: PMC3514009.


  35. Allen-Ramey FC, Gupta S, Dibonaventura MD
    Patient characteristics, treatment patterns, and health outcomes among COPD phenotypes
    Int J Chron Obstruct Pulmon Dis. 2012;7:779-87. doi: 10.2147/COPD.S35501. Epub 2012 Nov 22.PubMed Central PMCID: PMC3514008.


  36. Kim V, Criner GJ
    Chronic Bronchitis and COPD
    Am J Respir Crit Care Med. 2012 Nov 29.


  37. Muñoz-Barrutia A, Ceresa M, Artaechevarria X, Montuenga LM, Ortiz-de-Solorzano C
    Quantification of lung damage in an elastase-induced mouse model of emphysema
    Int J Biomed Imaging. 2012;2012:734734. doi: 10.1155/2012/734734. Epub 2012 Nov 8.PubMed Central PMCID: PMC3503307.


  38. Lee SW, Kim DR, Kim TJ, Paik JH, Chung JH, Jheon S, Huh JW, Lee JH, Lee CT
    The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers
    Respir Res. 2012 Nov 21;13(1):106.


  39. Centers for Disease Control and Prevention (CDC)
    Chronic obstructive pulmonary disease among adults - United States, 2011
    MMWR Morb Mortal Wkly Rep. 2012 Nov 23;61(46):938-43


  40. Warburton D, Shi W, Xu B
    TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?
    Am J Physiol Lung Cell Mol Physiol. 2012 Nov 16.


  41. Wang Z, Gu S, Leader JK, Kundu S, Tedrow JR, Sciurba FC, Gur D, Siegfried JM, Pu J
    Optimal threshold in CT quantification of emphysema
    Eur Radiol. 2012 Nov 1.


  42. CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD
    Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression
    Nat Med. 2012 Nov;18(11):1711-5. doi: 10.1038/nm.2971. Epub 2012 Oct 7. PubMed Central PMCID: PMC3493851


  43. An CH, Wang XM, Lam HC, Ifedigbo E, Washko GR, Ryter SW, Choi AM
    TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema
    Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L748-57. doi: 10.1152/ajplung.00102.2012. Epub 2012 Sep 14. PubMed Central PMCID: PMC3517684


  44. Yoshida S, Minematsu N, Chubachi S, Nakamura H, Miyazaki M, Tsuduki K, Takahashi S, Miyasho T, Iwabuchi T, Takamiya R, Tateno H, Mouded M, Shapiro SD, Asano K, Betsuyaku T
    Annexin V decreases PS-mediated macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice
    Am J Physiol Lung Cell Mol Physiol. 2012 Nov 15;303(10):L852-60. doi: 10.1152/ajplung.00066.2012. Epub 2012 Sep 7.


  45. Kirby M, Svenningsen S, Owrangi A, Wheatley A, Farag A, Ouriadov A, Santyr GE, Etemad-Rezai R, Coxson HO, McCormack DG, Parraga G
    Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease.
    Radiology. 2012 Nov;265(2):600-10. doi: 10.1148/radiol.12120485. Epub 2012 Sep 5.


  46. Romme EA, Murchison JT, Phang KF, Jansen FH, Rutten EP, Wouters EF, Smeenk FW, Van Beek EJ, Macnee W
    Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD
    J Bone Miner Res. 2012 Nov;27(11):2338-43. doi: 10.1002/jbmr.1678.


  47. Hartman JE, Ten Hacken NH, Klooster K, Boezen HM, de Greef MH, Slebos DJ
    The minimal important difference for residual volume in patients with severe emphysema
    Eur Respir J. 2012 Nov;40(5):1137-41. doi: 10.1183/09031936.00219111. Epub 2012 Mar 22.



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  48. Zarowitz BJ, O'Shea T.
    Chronic obstructive pulmonary disease: prevalence, characteristics, and pharmacologic treatment in nursing home residents with cognitive impairment.
    J Manag Care Pharm. 2012 Oct;18(8):598-606.


  49. Yilmaz C, Dane DM, Patel NC, Hsia CC.
    Quantifying Heterogeneity in Emphysema from High-Resolution Computed Tomography: A Lung Tissue Research Consortium Study.
    10.1016/j.acra.2012.09.013. [Epub ahead of print]


  50. Chen LF, Wang CH, Chou PC, Ho SC, Joa WC, Sheng TF, Kuo HP.
    Association Between Emphysema Score, Six-Minute Walk and Cardiopulmonary Exercise Tests in COPD.
    Open Respir Med J. 2012;6:104-10. doi: 10.2174/1874306401206010104. Epub 2012 Oct 2.


  51. Betsuyaku T, Fuke S, Inomata T, Kaga K, Morikawa T, Odajima N, Adair-Kirk T, Nishimura M.
    Bronchiolar epithelial catalase is diminished in smokers with mild COPD.
    Eur Respir J. 2012 Oct 25. [Epub ahead of print]


  52. Diaz AA, Han MK, Come CE, Estépar RS, Ross JC, Kim V, Dransfield MT, Curran-Everett D, Schroeder JD, Lynch DA, Tschirren J, Silverman EK, Washko GR.
    The Effect of Emphysema on Computed Tomographic Measures of Airway Dimensions in Smokers.
    Chest. 2012 Oct 8. doi: 10.1378/chest.12-0039. [Epub ahead of print]


  53. Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI.
    The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis.
    Int J Chron Obstruct Pulmon Dis. 2012;7:633-40. doi: 10.2147/COPD.S34929. Epub 2012 Oct 4. PubMed Central PMCID: PMC3468058.


  54. Ubhi BK, Cheng KK, Dong J, Janowitz T, Jodrell D, Tal-Singer R, Macnee W, Lomas DA, Riley JH, Griffin JL, Connor SC.
    Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD.
    Mol Biosyst. 2012 Oct 30;8(12):3125-33. doi: 10.1039/c2mb25194a.


  55. Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD.
    Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.
    Nat Med. 2012 Nov;18(11):1711-5. doi: 10.1038/nm.2971. Epub 2012 Oct 7. PubMed Central PMCID: PMC3493851.


  56. Pellegrino R, Antonelli A.
    Unfolding the mechanisms of progression of pulmonary emphysema in COPD.
    Eur Respir J. 2012 Oct;40(4):801-3.


  57. Hackx M, Bankier AA, Gevenois PA.
    Chronic obstructive pulmonary disease: CT quantification of airways disease.
    Radiology. 2012 Oct;265(1):34-48.


  58. Ginsburg SB, Lynch DA, Bowler RP, Schroeder JD.
    Automated texture-based quantification of centrilobular nodularity and centrilobular emphysema in chest CT images.
    Acad Radiol. 2012 Oct;19(10):1241-51. doi: 10.1016/j.acra.2012.04.020.


  59. Szabari MV, Parameswaran H, Sato S, Hantos Z, Bartolák-Suki E, Suki B.
    Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema.
    Am J Physiol Lung Cell Mol Physiol. 2012 Oct;303(7):L567-74. doi: 10.1152/ajplung.00217.2012. Epub 2012 Aug 3. PubMed Central PMCID: PMC3469589.


  60. Tanabe N, Muro S, Fuseya Y, Sato S, Oguma T, Kiyokawa H, Takahashi T, Kinose D, Hoshino Y, Kubo T, Hirai T, Mishima M.
    Peri-diaphragmatic lung volume assessed by computed tomography correlates with quality of life in patients with chronic obstructive pulmonary disease.
    Respirology. 2012 Oct;17(7):1137-43. doi: 10.1111/j.1440-1843.2012.02221.x.


  61. Darby AC, Waterhouse JC, Stevens V, Billings CG, Billings CG, Burton CM, Young C, Wight J, Blanc PD, Fishwick D.
    Chronic obstructive pulmonary disease among residents of an historically industrialised area.
    Thorax. 2012 Oct;67(10):901-7. doi: 10.1136/thoraxjnl-2011-200543. Epub 2012 Jun 28.


  62. Nie YC, Wu H, Li PB, Luo YL, Zhang CC, Shen JG, Su WW.
    Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease.
    Pulm Pharmacol Ther. 2012 Oct;25(5):349-56. doi: 10.1016/j.pupt.2012.06.004. Epub 2012 Jun 23.


  63. Mets OM, Willemink MJ, de Kort FP, Mol CP, Leiner T, Oudkerk M, Prokop M, de Jong PA.
    The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions.
    Eur Radiol. 2012 Oct;22(10):2103-9. doi: 10.1007/s00330-012-2489-z. Epub 2012 May 23. PubMed Central PMCID: PMC3431467.


  64. Ziegler-Heitbrock L, Frankenberger M, Heimbeck I, Burggraf D, Wjst M, Häussinger K, Brightling C, Gupta S, Parr D, Subramanian D, Singh D, Kolsum U, Boschetto P, Potena A, Gorecka D, Nowinski A, Barta I, Döme B, Strausz J, Greulich T, Vogelmeier C, Bals R, Hohlfeld JM, Welte T, Venge P, Gut I, Boland A, Olaso R, Hager J, Hiemstra P, Rabe KF, Unmüßig M, Müller-Quernheim J, Prasse A.
    The EvA study: aims and strategy.
    Eur Respir J. 2012 Oct;40(4):823-9. Epub 2012 Mar 22.


  65. Mohamed Hoesein FA, van Rikxoort E, van Ginneken B, de Jong PA, Prokop M, Lammers JW, Zanen P.
    Computed tomography-quantified emphysema distribution is associated with lung function decline.
    Eur Respir J. 2012 Oct;40(4):844-50. Epub 2012 Feb 9.


  66. Cheng HM, Chang PY, Chiang KH, Huang HW, Lee CC.
    Prevalence and characteristics of paratracheal air cysts and their association with emphysema in a general population.
    Eur J Radiol. 2012 Oct;81(10):2673-7. doi: 10.1016/j.ejrad.2011.10.013. Epub 2011 Nov 17.


  67. Tanabe N, Muro S, Sato S, Tanaka S, Oguma T, Kiyokawa H, Takahashi T, Kinose D, Hoshino Y, Kubo T, Hirai T, Mishima M.
    Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease.
    PLoS One. 2012;7(9):e44993. doi: 10.1371/journal.pone.0044993. Epub 2012 Sep 18.PubMed Central PMCID: PMC3445600.


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  68. Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C, Pollard L, Wild JM, Lawrie A, Lawson R, Sabroe I, Kiely DG.
    Pulmonary hypertension in COPD: results from the ASPIRE registry.
    Eur Respir J. 2012 Sep 27. [Epub ahead of print]


  69. Scarpa MC, Baraldo S, Marian E, Turato G, Calabrese F, Saetta M, Maestrelli P.
    Ceramide Expression and Cell Homeostasis in Chronic Obstructive Pulmonary Disease.
    Respiration. 2012 Sep 25. [Epub ahead of print]


  70. Rezende Gonçalves J, Corso Pereira M, Figueiras Pedreira De Cerqueira EM, Oliveira Magro D, Mello Moreira M, Paschoal IA.
    Severe obstructive disease: Similarities and differences between smoker and non-smoker patients with COPD and/or bronchiectasis.
    Rev Port Pneumol. 2012 Sep 24. pii: S0873-2159(12)00097-9. doi: 10.1016/j.rppneu.2012.05.003. [Epub ahead of print] English, Portuguese.


  71. Fried TR, Vaz Fragoso CA, Rabow MW.
    Caring for the older person with chronic obstructive pulmonary disease.
    JAMA. 2012 Sep 26;308(12):1254-63.


  72. Lanzetti M, da Costa CA, Nesi RT, Barroso MV, Martins V, Victoni T, Lagente V, Pires KM, E Silva PM, Resende AC, Porto LC, Benjamim CF, Valença SS.
    Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.
    Free Radic Biol Med. 2012 Sep 19. pii: S0891-5849(12)01140-9. doi: 10.1016/j.freeradbiomed.2012.09.015. [Epub ahead of print]


  73. An CH, Wang XM, Lam HC, Ifedigbo E, Washko GR, Ryter SW, Choi AM.
    Deficiency Promotes Autophagy during Cigarette Smoke-Induced Pulmonary Emphysema.
    Am J Physiol Lung Cell Mol Physiol. 2012 Sep 14. [Epub ahead of print]


  74. Yoshida S, Minematsu N, Chubachi S, Nakamura H, Miyazaki M, Tsuduki K, Takahashi S, Miyasho T, Iwabuchi T, Takamiya R, Tateno H, Mouded M, Shapiro SD, Asano K, Betsuyaku T.
    Annexin V decreases PS-mediated macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice.
    Am J Physiol Lung Cell Mol Physiol. 2012 Sep 7. [Epub ahead of print]


  75. Davies N.
    Symptom "accommodation" in patients with COPD.
    Nurs Times. 2012 Aug 21-Sep 3;108(34-35):17, 19-20. Review.


  76. Graff JW, Powers LS, Dickson AM, Kim J, Reisetter AC, Hassan IH, Kremens K, Gross TJ, Wilson ME, Monick MM.
    Cigarette Smoking Decreases Global MicroRNA Expression in Human Alveolar Macrophages.
    PLoS One. 2012;7(8):e44066. Epub 2012 Aug 29. PMCID: PMC3430644.


  77. Kirby M, Svenningsen S, Owrangi A, Wheatley A, Farag A, Ouriadov A, Santyr GE, Etemad-Rezai R, Coxson HO, McCormack DG, Parraga G.
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  164. Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I.
    SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
    J Clin Invest. 2012 Jun 1;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1.


  165. Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, Washko GR, Martinez FJ, Han MK, COPDGene Investigators.
    Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.
    Thorax. 2012 May;67(5):399-406.


  166. Brulotte CA, Lang ES.
    Acute exacerbations of chronic obstructive pulmonary disease in the emergency department.
    Med Clin North Am. 2012 May;30(2):223-47, vii.


  167. Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT.
    NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.
    J Immunol. 2012 May 1;188(9):4468-75. Epub 2012 Mar 30. PubMed Central PMCID: PMC3331972.


  168. Gao C, Maeno T, Ota F, Ueno M, Korekane H, Takamatsu S, Shirato K, Matsumoto A, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Betsuyaku T, Taniguchi N.
    Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema: IMPLICATION OF ABERRANT TRANSFORMING GROWTH FACTOR-β SIGNALING AND MATRIX METALLOPROTEINASE GENE EXPRESSION.
    J Biol Chem. 2012 May 11;287(20):16699-708. Epub 2012 Mar 20. PubMed Central PMCID: PMC3351343.


  169. Celli BR, Locantore N, Yates J, Tal-Singer R, Miller BE, Bakke P, Calverley P, Coxson H, Crim C, Edwards LD, Lomas DA, Duvoix A, Macnee W, Rennard S, Silverman E, Vestbo J, Wouters E, Agustí A; for the ECLIPSE Investigators.
    Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease.
    Am J Respir Crit Care Med. 2012 May 15;185(10):1065-1072.


  170. Moga AM, de Marchie M, Saey D, Spahija J.
    Mechanisms of non-pharmacologic adjunct therapies used during exercise in COPD.
    Med. 2012 May;106(5):614-26. Epub 2012 Feb 15. Review.


  171. Rinaldi M, Maes K, De Vleeschauwer S, Thomas D, Verbeken EK, Decramer M, Janssens W, Gayan-Ramirez GN.
    Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice.
    Dis Model Mech. 2012 May;5(3):333-41. Epub 2012 Jan 25. PubMed Central PMCID: PMC3339827.


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  172. Beşir FH, Mahmutyazıcıoğlu K, Aydın L, Altın R, Asil K, Gündoğdu S.
    The benefit of expiratory-phase quantitative CT densitometry in the early diagnosis of chronic obstructive pulmonary disease.
    Diagn Interv Radiol. 2012 May-Jun;18(3):248-54.


  173. Tanabe N, Muro S, Tanaka S, Sato S, Oguma T, Kiyokawa H, Takahashi T, Kinose D, Hoshino Y, Kubo T, Ogawa E, Hirai T, Mishima M.
    Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease.
    Respir Res. 2012 Apr 18;13(1):31. [Epub ahead of print]


  174. Ogura-Tomomatsu H, Asano K, Tomomatsu K, Miyata J, Ohmori N, Kodama M, Ueda S, Takihara T, Tanaka K, Kamiishi N, Suzuki Y, Fukunaga K, Oguma T, Sayama K, Betsuyaku T.
    Predictors of Osteoporosis and Vertebral Fractures in Patients Presenting with Moderate-to-Severe Chronic Obstructive Lung Disease.
    COPD. 2012 Apr 11. [Epub ahead of print]


  175. COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, van Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG.
    A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation.
    COPD. 2012 Apr;9(2):151-9. Epub 2012 Mar 19.


  176. Rosenberg SR, Kalhan R.
    Biomarkers in chronic obstructive pulmonary disease.
    Transl Res. 2012 Apr;159(4):228-37. Epub 2012 Feb 7. Review.


  177. Hachulla AL, Pontana F, Wemeau-Stervinou L, Khung S, Faivre JB, Wallaert B, Cazaubon JF, Duhamel A, Perez T, Devos P, Remy J, Remy-Jardin M.
    Krypton ventilation imaging using dual-energy CT in chronic obstructive pulmonary disease patients: initial experience.
    Radiology. 2012 Apr;263(1):253-9. Epub 2012 Feb 13.


  178. Decramer M, Janssens W, Miravitlles M.
    Chronic obstructive pulmonary disease.
    Lancet. 2012 Apr 7;379(9823):1341-51. Epub 2012 Feb 6. Review.


  179. Ruwanpura SM, McLeod L, Miller A, Jones J, Vlahos R, Ramm G, Longano A, Bardin PG, Bozinovski S, Anderson GP, Jenkins BJ.
    Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice.
    Am J Physiol Lung Cell Mol Physiol. 2012 Apr;302(7):L627-39. doi: 10.1152/ajplung.00285.2011. Epub 2012 Jan 20.


  180. Kastelik JA, Lowe D, Stone RA, Buckingham RJ, Roberts CM.
    National audit of supported discharge programmes for management of acute exacerbations of chronic obstructive pulmonary disease 2008.
    Thorax. 2012 Apr;67(4):371-3. Epub 2012 Jan 16.


  181. Braber S, Thio M, Blokhuis BR, Henricks PA, Koelink PJ, Groot Kormelink T, Bezemer GF, Kerstjens HA, Postma DS, Garssen J, Kraneveld AD, Redegeld FA, Folkerts G.
    An Association between Neutrophils and Immunoglobulin Free Light Chains in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
    Am J Respir Crit Care Med. 2012 Apr 15;185(8):817-24. Epub 2012 Jan 6.


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  182. Andersen KH, Iversen M, Kjaergaard J, Mortensen J, Nielsen-Kudsk JE, Bendstrup E, Videbaek R, Carlsen J.
    Prevalence, predictors, and survival in pulmonary hypertension related to end-stage chronic obstructive pulmonary disease.
    J Heart Lung Transplant. 2012 Apr;31(4):373-80. Epub 2012 Jan 9.


  183. Mets OM, de Jong PA, van Ginneken B, Gietema HA, Lammers JW.
    Quantitative computed tomography in COPD: possibilities and limitations.
    Lung. 2012 Apr;190(2):133-45. Epub 2011 Dec 17. PubMed Central PMCID: PMC3310986.


  184. Waschki B, Spruit MA, Watz H, Albert PS, Shrikrishna D, Groenen M, Smith C, Man WD, Tal-Singer R, Edwards LD, Calverley PM, Magnussen H, Polkey MI, Wouters EF.
    Physical activity monitoring in COPD: compliance and associations with clinical characteristics in a multicenter study.
    Respir Med. 2012 Apr;106(4):522-30. Epub 2011 Nov 25.


  185. Lykkegaard J, Søndergaard J, Kragstrup J, Rømhild Davidsen J, Knudsen T, Andersen M.
    All Danish first-time COPD hospitalisations 2002-2008: incidence, outcome, patients, and care.
    Respir Med. 2012 Apr;106(4):549-56. Epub 2011 Nov 23.


  186. Menn P, Heinrich J, Huber RM, Jörres RA, John J, Karrasch S, Peters A, Schulz H, Holle R; KORA Study Group.
    Direct medical costs of COPD--an excess cost approach based on two population-based studies.
    Respir Med. 2012 Apr;106(4):540-8. Epub 2011 Nov 18.


  187. Barr RG, Ahmed FS, Carr JJ, Hoffman EA, Jiang R, Kawut SM, Watson K.
    Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study.
    Eur Respir J. 2012 Apr;39(4):846-54. Epub 2011 Oct 27.


  188. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R; COPDGene Investigators.
    Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest.
    2012 Apr;141(4):867-75. Epub 2011 Sep 29. PubMed Central PMCID: PMC3318949.


  189. Park SJ, Lee CH, Goo JM, Heo CY, Kim JH.
    Inter-scan repeatability of CT-based lung densitometry in the surveillance of emphysema in a lung cancer screening setting.
    Eur J Radiol. 2012 Apr;81(4):e554-60. Epub 2011 Jul 12.


  190. Danielsson P, Ólafsdóttir IS, Benediktsdóttir B, Gíslason T, Janson C.
    The prevalence of chronic obstructive pulmonary disease in Uppsala, Sweden—the Burden of Obstructive Lung Disease (BOLD) study: cross-sectional population-based study.
    Clin Respir J. 2012 Apr;6(2):120-7. doi: 10.1111/j.1752-699X.2011.00257.x. Epub 2011 Jul 6.


  191. Ankersmit HJ, Nickl S, Hoeltl E, Toepker M, Lambers C, Mitterbauer A, Kortuem B, Zimmermann M, Moser B, Bekos C, Steinlechner B, Hofbauer H, Klepetko W, Schenk P, Dome B.
    Increased Serum Levels of HSP27 as a Marker for Incipient Chronic Obstructive Pulmonary Disease in Young Smokers.
    Respiration. 2012 Mar 14. [Epub ahead of print]


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  192. Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G, Lucattelli M.
    Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice.
    Am J Respir Cell Mol Biol. 2012 Mar 29. [Epub ahead of print]


  193. Chandra D, Stamm JA, Palevsky PM, Leader JK, Fuhrman CR, Zhang Y, Bon J, Duncan SR, Branch RA, Weissfeld J, Gur D, Gladwin MT, Sciurba FC.
    The Relationship Between Pulmonary Emphysema and Kidney Function in Smokers.
    Chest. 2012 Mar 29. [Epub ahead of print]


  194. Rinaldi M, Lehouck A, Heulens N, Lavend'homme R, Carlier V, Saint-Remy JM, Decramer M, Gayan-Ramirez G, Janssens W.
    Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease.
    Thorax. 2012 Mar 22. [Epub ahead of print]


  195. Hartman JE, Ten Hacken NH, Klooster K, Boezen HM, de Greef MH, Slebos DJ.
    The minimal important difference for residual volume in patients with severe emphysema.
    Eur Respir J. 2012 Mar 22. [Epub ahead of print]


  196. Ziegler-Heitbrock L, Frankenberger M, Heimbeck I, Burggraf D, Wjst M, Häussinger K, Brightling C, Gupta S, Parr D, Subramanian D, Singh D, Kolsum U, Boschetto P, Potena A, Gorecka D, Nowinksi A, Barta I, Döme B, Strausz J, Greulich T, Vogelmeier C, Bals R, Hohlfeld J, Welte T, Venge P, Gut I, Boland A, Olaso R, Hager J, Hiemstra P, Rabe KF, Unmüßig M, Müller-Quernheim J, Prasse A.
    The EvA study: aims and strategy.
    Eur Respir J. 2012 Mar 22. [Epub ahead of print]


  197. Gao C, Maeno T, Ota F, Ueno M, Korekane H, Takamatsu S, Shirato K, Matsumoto A, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Betsuyaku T, Taniguchi N.
    Sensitivity of heterozygous α1, 6- fucosyltransferase knock out mice to cigarette smoke-induced emphysema: implication of aberrant TGF-β signaling and MMP gene expression.
    J Biol Chem. 2012 Mar 20. [Epub ahead of print]


  198. Camiciottoli G, Bigazzi F, Bartolucci M, Cestelli L, Paoletti M, Diciotti S, Cavigli E, Magni C, Buonasera L, Mascalchi M, Pistolesi M.
    BODE-index, modified BODE-index and ADO-score in Chronic Obstructive Pulmonary Disease: Relationship with COPD phenotypes and CT lung density changes.
    COPD. 2012 Mar 20. [Epub ahead of print]


  199. Barr CC, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, Macnee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG.
    A Combined Pulmonary-Radiology Workshop for Visual Evaluation of COPD: Study Design, Chest CT Findings and Concordance with Quantitative Evaluation.
    COPD. 2012 Apr;9(2):151-159. Epub 2012 Mar 19.


  200. Celli BR, Locantore N, Yates J, Tal-Singer R, Miller BE, Bakke P, Calverley P, Coxson H, Crim C, Edwards LD, Lomas DA, Duvoix A, Macnee W, Rennard S, Silverman E, Vestbo J, Wouters E, Agustí A; for the ECLIPSE investigators.
    Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease.
    Am J Respir Crit Care Med. 2012 Mar 23. [Epub ahead of print]


  201. Graat-Verboom L, Smeenk FW, van den Borne BE, Spruit MA, Donkers-van Rossum AB, Aarts RP, Wouters EF.
    Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: A case control study.
    Bone. 2012 Mar 9. [Epub ahead of print]


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  202. Mogulkoc U, Coskunpinar E, Aynaci E, Cağlar E, Ortakoylu MG, Ozkan G, Oltulu YM, Eraltan IY.
    Is MMP-7 Gene Polymorphism a Possible Risk Factor for Chronic Obstructive Pulmonary Disease in Turkish Patients.
    Genet Test Mol Biomarkers. 2012 Mar 14. [Epub ahead of print]


  203. Centers for Disease Control and Prevention (CDC).
    Chronic obstructive pulmonary disease and associated health-care resource use - North Carolina, 2007 and 2009.
    MMWR Morb Mortal Wkly Rep. 2012 Mar 2;61(8):143-6.


  204. Hart JE, Eisen EA, Laden F.
    Occupational diesel exhaust exposure as a risk factor for chronic obstructive pulmonary disease.
    Curr Opin Pulm Med. 2012 Mar;18(2):151-4. Review.


  205. Miravitlles M, Calle M, Soler-Cataluña JJ.
    Clinical phenotypes of COPD: identification, definition and implications for guidelines.
    Arch Bronconeumol. 2012 Mar;48(3):86-98. Epub 2011 Dec 22. English, Spanish.


  206. Gjerde B, Bakke PS, Ueland T, Hardie JA, Eagan TM.
    The prevalence of undiagnosed renal failure in a cohort of COPD patients in western Norway.
    Respir Med. 2012 Mar;106(3):361-6. Epub 2011 Nov 29.


  207. Naberan K, Azpeitia A, Cantoni J, Miravitlles M.
    Impairment of quality of life in women with chronic obstructive pulmonary disease.
    Respir Med. 2012 Mar;106(3):367-73. Epub 2011 Oct 20.


  208. Aaron SD, Donaldson GC, Whitmore GA, Hurst JR, Ramsay T, Wedzicha JA.
    Time course and pattern of COPD exacerbation onset.
    Thorax. 2012 Mar;67(3):238-43. Epub 2011 Oct 18.


  209. Perez X, Wisnivesky JP, Lurslurchachai L, Kleinman LC, Kronish IM.
    Barriers to adherence to COPD guidelines among primary care providers.
    Respir Med. 2012 Mar;106(3):374-81. Epub 2011 Oct 13.


  210. Williams JE, Green RH, Warrington V, Steiner MC, Morgan MD, Singh SJ.
    Development of the i-BODE: validation of the incremental shuttle walking test within the BODE index.
    Respir Med. 2012 Mar;106(3):390-6. Epub 2011 Oct 5.


  211. Inonu H, Doruk S, Sahin S, Erkorkmaz U, Celik D, Celikel S, Seyfikli Z.
    Oxidative stress levels in exhaled breath condensate associated with COPD and smoking.
    Respir Care. 2012 Mar;57(3):413-9. Epub 2011 Sep 26.


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  212. Diaz AA, Come CE, Ross JC, San José Estépar R, Han MK, Loring SH, Silverman EK, Washko GR; COPDGene Investigators.
    Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD.
    Chest. 2012 Mar;141(3):736-44. Epub 2011 Sep 22. PubMed Central PMCID: PMC3296457.


  213. Rosenberg SR, Kalhan R.
    Biomarkers in chronic obstructive pulmonary disease.
    Transl Res. 2012 Apr;159(4):228-37. Epub 2012 Feb 7.


  214. Garfield JL, Marchetti N, Gaughan JP, Steiner RM, Criner GJ.
    Total lung capacity by plethysmography and high-resolution computed tomography in COPD.
    Int J Chron Obstruct Pulmon Dis. 2012;7:119-26. Epub 2012 Feb 22.


  215. Maclay JD, McAllister DA, Rabinovich R, Haq I, Maxwell S, Hartland S, Connell M, Murchison JT, van Beek EJ, Gray RD, Mills NL, Macnee W.
    Systemic elastin degradation in chronic obstructive pulmonary disease.
    Thorax. 2012 Feb 28.


  216. Kiyokawa H, Muro S, Oguma T, Sato S, Tanabe N, Takahashi T, Kudo M, Kinose D, Kondoh H, Kubo T, Hoshino Y, Ogawa E, Hirai T, Mishima M.
    Impact of COPD Exacerbations on Osteoporosis Assessed by Chest CT Scan.
    COPD. 2012 Feb 23


  217. Timmins SC, Diba C, Farrow CE, Schoeffel RE, Berend N, Salome CM, King GG.
    The relationship between airflow obstruction, emphysema extent and small airways function in COPD.
    Chest. 2012 Feb 16.


  218. Hachulla AL, Pontana F, Wemeau-Stervinou L, Khung S, Faivre JB, Wallaert B, Cazaubon JF, Duhamel A, Perez T, Devos P, Remy J, Remy-Jardin M.
    Krypton Ventilation Imaging Using Dual-Energy CT in Chronic Obstructive Pulmonary Disease Patients: Initial Experience.
    Radiology. 2012 Feb 13.


  219. Mohamed Hoesein FA, van Rikxoort E, van Ginneken B, de Jong PA, Prokop M, Lammers JW, Zanen P.
    CT-quantified emphysema distribution is associated with lung function decline.
    Eur Respir J. 2012 Feb 23.


  220. Swift I, Satti A, Kim V, Make BJ, Newell J, Steiner RM, Wilson C, Murphy JR, Silverman EK, Criner GJ; COPDGene® Investigators.
    Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids.
    COPD. 2012 Feb;9(1):29-35.


  221. Reddy NM, Vegiraju S, Irving A, Paun BC, Luzina IG, Atamas SP, Biswal S, Ana NA, Mitzner W, Reddy SP.
    Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation.
    Am J Pathol. 2012 Feb;180(2):562-74.


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  222. Gulbas G, Gunen H, In E, Kilic T.
    Long-term follow-up of chronic obstructive pulmonary disease patients on long-term oxygen treatment.
    Int J Clin Pract. 2012 Feb;66(2):152-7. doi: 10.1111/j.1742-1241.2011.02833.x. Epub 2011 Dec 20.


  223. Mascalchi M, Diciotti S, Sverzellati N, Camiciottoli G, Ciccotosto C, Falaschi F, Zompatori M.
    Low agreement of visual rating for detailed quantification of pulmonary emphysema in whole-lung CT.
    Acta Radiol. 2012 Feb 1;53(1):53-60. Epub 2011 Nov 23.


  224. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; ICGN Investigators; ECLIPSE Investigators; COPDGene Investigators.
    A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
    Hum Mol Genet. 2012 Feb 15;21(4):947-57. Epub 2011 Nov 11.


  225. Lee JH, Hanaoka M, Kitaguchi Y, Kraskauskas D, Shapiro L, Voelkel NF, Taraseviciene-Stewart L.
    Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema.
    Lung. 2012 Feb;190(1):69-82. Epub 2011 Oct 21.


  226. Chong D, Brown MS, Kim HJ, van Rikxoort EM, Guzman L, McNitt-Gray MF, Khatonabadi M, Galperin-Aizenberg M, Coy H, Yang K, Jung Y, Goldin JG.
    Reproducibility of volume and densitometric measures of emphysema on repeat computed tomography with an interval of 1 week.
    Eur Radiol. 2012 Feb;22(2):287-94. Epub 2011 Oct 20.


  227. van Rikxoort EM, Goldin JG, Galperin-Aizenberg M, Abtin F, Kim HJ, Lu P, van Ginneken B, Shaw G, Brown MS.
    A method for the automatic quantification of the completeness of pulmonary fissures: evaluation in a database of subjects with severe emphysema.
    Eur Radiol. 2012 Feb;22(2):302-9. Epub 2011 Oct 8.


  228. Ezzie ME, Crawford M, Cho JH, Orellana R, Zhang S, Gelinas R, Batte K, Yu L, Nuovo G, Galas D, Diaz P, Wang K, Nana-Sinkam SP.
    Gene expression networks in COPD: microRNA and mRNA regulation.
    Thorax. 2012 Feb;67(2):122-31. Epub 2011 Sep 22.


  229. Ishii T, Hagiwara K, Kamio K, Ikeda S, Arai T, Mieno MN, Kumasaka T, Muramatsu M, Sawabe M, Gemma A, Kida K.
    Involvement of surfactant protein D in emphysema revealed by genetic association study.
    Eur J Hum Genet. 2012 Feb;20(2):230-5. doi: 10.1038/ejhg.2011.183. Epub 2011 Sep 21.


  230. Verma A, Harrison A, Torun P, Vestbo J, Edwards R, Thornton J.
    Are pharmacists reducing COPD'S impact through smoking cessation and assessing inhaled steroid use?
    Respir Med. 2012 Feb;106(2):230-4. Epub 2011 Sep 7.


  231. Chavoshan B, Fournier M, Lewis MI, Porszasz J, Storer TW, Da X, Rambod M, Casaburi R.
    Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men.
    Respir Med. 2012 Feb;106(2):269-75. Epub 2011 Aug 16.


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Tratamiento de la EPOC

  1. Saluja B, Thakkar JN, Li H, Desai UR, Sakagami M.
    Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation.
    Pulm Pharmacol Ther. 2012 Dec 29. doi:pii: S1094-5539(12)00180-0. 10.1016/j.pupt.2012.12.009. [Epub ahead of print] PubMed PMID: 23280431.


  2. Longhini-Dos-Santos N, Barbosa-de-Oliveira VA, Kozma RH, Faria CA, Stessuk T, Frei F, Ribeiro-Paes JT.
    Cell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysema.
    Stem Cell Rev. 2012 Dec 16. [Epub ahead of print] PubMed PMID: 23242964.


  3. Aclidium bromide (Tudorza Pressair) for COPD.
    Med Lett Drugs Ther. 2012 Dec 10;54(1405):99-100. Review. PubMed PMID: 23223246.


  4. Mineo D, Mineo TC.
    Lung volume reduction surgery: a better understanding for a renewed challenge in the treatment of emphysema.
    Am J Respir Crit Care Med. 2012 Dec 1;186(11):1068-70. doi: 10.1164/rccm.201209-1751ED. PubMed PMID: 23204369


  5. Barua A, Vaughan P, Wotton R, Naidu B.
    Do endobronchial valves improve outcomes in patients with emphysema?
    Interact Cardiovasc Thorac Surg. 2012 Dec;15(6):1072-6. doi: 10.1093/icvts/ivs371. Epub 2012 Sep 3. PubMed PMID: 22945849; PubMed Central PMCID: PMC3501299.


  6. Kim V, Kretschman DM, Sternberg AL, DeCamp MM Jr, Criner GJ; National Emphysema Treatment Trial Research Group.
    Weight gain after lung reduction surgery is related to improved lung function and ventilatory efficiency.
    Am J Respir Crit Care Med. 2012 Dec 1;186(11):1109-16. doi: 10.1164/rccm.201203-0538OC. Epub 2012 Aug 9. PubMed PMID: 22878279.


  7. Deslee G, Barbe C, Bourdin A, Durand-Zaleski I, Dutau H, Jolly D, Jounieaux V, Kessler R, Mal H, Pison C, Thiberville L, Vergnon JM, Marquette CH
    Cost-effectiveness of lung volume reduction coil treatment in emphysema. STIC REVOLENS
    Rev Mal Respir. 2012 Nov;29(9):1157-64. doi: 10.1016/j.rmr.2012.09.010. Epub 2012 Oct 12. French


  8. Muyal JP, Muyal V, Kotnala S, Kumar D, Bhardwaj H
    Therapeutic Potential of Growth Factors in Pulmonary Emphysematous Condition
    Lung. 2012 Nov 17


  9. Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, Lucattelli M, Polverino F, Lungarella G, Cirino G, Rossi F, D'Agostino B.
    Skeletal Muscle Oxidative Metabolism in an Animal Model of Pulmonary Emphysema: Formoterol and Skeletal Muscle Dysfunction
    Am J Respir Cell Mol Biol. 2012 Nov 9.


  10. Destors M, Aniwidyaningsih W, Jankowski A, Pison C
    Endoscopic volume reduction before or after lung transplantation
    Eur J Cardiothorac Surg. 2012 Nov;42(5):897-8. doi: 10.1093/ejcts/ezs352. Epub 2012 Jun 13


  11. Yoshida M, Nakano T, Fukuyama S, Matsumoto T, Eguchi M, Moriwaki A, Takata S, Machida K, Kanaya A, Matsumoto K, Nakanishi Y, Inoue H.
    Effects of tiotropium on lung function in severe asthmatics with or without emphysematous changes.
    Pulm Pharmacol Ther. 2012 Oct 13. doi:pii: S1094-5539(12)00144-7. 10.1016/j.pupt.2012.09.007. [Epub ahead of print]


  12. Valipour A, Kramer MR, Stanzel F, Kempa A, Asadi S, Fruchter O, Eberhardt R, Herth FJ, Ingenito EP.
    Physiological modeling of responses to upper versus lower lobe lung volume reduction in homogeneous emphysema.
    Front Physiol. 2012;3:387. doi: 0.3389/fphys.2012.00387. Epub 2012 Oct 1. PubMed Central PMCID: PMC3461642.


  13. Miravitlles M, José Soler-Cataluña J, Calle M, Soriano JB.
    Treatment of COPD by clinical phenotypes. Putting old evidence into clinical practice.
    Eur Respir J. 2012 Oct 11. [Epub ahead of print]


  14. Lee P, Khoo KL.
    A review of current bronchoscopic interventions for obstructive airway diseases.
    Ther Adv Respir Dis. 2012 Oct;6(5):297-307. Epub 2012 Aug 9.


  15. Shrikrishna D, Astin R, Kemp PR, Hopkinson NS.
    Renin-angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease.
    Clin Sci (Lond). 2012 Oct;123(8):487-98. Review.


  16. Lammi MR, Ciccolella D, Marchetti N, Kohler M, Criner GJ.
    Increased oxygen pulse after lung volume reduction surgery is associated with reduced dynamic hyperinflation.
    Eur Respir J. 2012 Oct;40(4):837-43. Epub 2012 Jan 20.


  17. Arango E, Espinosa D, Illana J, Carrasco G, Moreno P, Algar FJ, Alvarez A, Cerezo F, Baamonde C, Requejo A, Redel J, Vaquero J, Santos F, Salvatierra A.
    Lung volume reduction surgery after lung transplantation for emphysema-chronic obstructive pulmonary disease.
    Transplant Proc. 2012 Sep;44(7):2115-7. doi: 10.1016/j.transproceed.2012.07.068.


  18. Coll E, Santos F, Ussetti P, Canela M, Borro JM, De La Torre M, Varela A, Zurbano F, Mons R, Morales P, Pastor J, Salvatierra A, de Pablo A, Gámez P, Moreno A, Solé J, Román A.
    The Spanish Lung Transplant Registry: First Report of Results (2006-2010).
    Arch Bronconeumol. 2012 Aug 28. [Epub ahead of print] English, Spanish.


  19. Esquinas Rodriguez AM, Ioannis P.
    A link of non-invasive ventilation in chronic hypercapnic COPD patients with pulmonary hypertension. A new index of prognosis?
    Eur Rev Med Pharmacol Sci. 2012 Aug;16(8):1133-4; author reply 1135-6.


  20. Wedzicha JA, Vestbo J.
    Can patients with COPD self-manage?
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  21. Bodas M, Tran I, Vij N.
    Therapeutic strategies to correct proteostasis-imbalance in chronic obstructive lung diseases.
    Curr Mol Med. 2012 Aug;12(7):807-14.


  22. Albert P, Agusti A, Edwards L, Tal-Singer R, Yates J, Bakke P, Celli BR, Coxson HO, Crim C, Lomas DA, Macnee W, Miller B, Rennard S, Silverman EK, Vestbo J, Wouters E, Calverley P.
    Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease.
    Thorax. 2012 Aug;67(8):701-8. Epub 2012 Jun 13.


  23. Tan WC, Vollmer WM, Lamprecht B, Mannino DM, Jithoo A, Nizankowska-Mogilnicka E, Mejza F, Gislason T, Burney PG, Buist AS; BOLD Collaborative Research Group.
    Worldwide patterns of bronchodilator responsiveness: results from the Burden of Obstructive Lung Disease study.
    Thorax. 2012 Aug;67(8):718-26. Epub 2012 Apr 29.


  24. Wilson H, Carby M, Beddow E.
    Lung volume reduction surgery for native lung hyperinflation following single-lung transplantation for emphysema: which patients?
    Eur J Cardiothorac Surg. 2012 Sep;42(3):410-3. Epub 2012 Mar 1.


  25. Stolk J, Stockley RA, Stoel BC, Cooper BG, Piitulainen E, Seersholm N, Chapman KR, Burdon JG, Decramer M, Abboud RT, Mannes GP, Wouters EF, Garrett JE, Barros-Tizon JC, Russi EW, Lomas DA, MacNee WA, Rames A.
    Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor.
    Eur Respir J. 2012 Aug;40(2):306-12. Epub 2012 Jan 26.


  26. Wenzel RP, Fowler AA 3rd, Edmond MB.
    Antibiotic prevention of acute exacerbations of COPD.
    N Engl J Med. 2012 Jul 26;367(4):340-7. Review.


  27. Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, López-Campos JL, Soriano JB, Ancochea J.
    [Spanish COPD Guidelines (GesEPOC): Pharmacological treatment of stable COPD].
    Aten Primaria. 2012 Jul;44(7):425-37. Epub 2012 Jun 15. Spanish.


  28. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, Decamp MM, Berger RL.
    An evidence-based estimate on the size of the potential patient pool for lung volume reduction surgery.
    Ann Thorac Surg. 2012 Jul;94(1):205-11. Epub 2012 May 8.


  29. Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, López-Campos JL, Soriano JB, Ancochea J.
    Spanish COPD Guidelines (GesEPOC): Pharmacological Treatment of Stable COPD.
    Arch Bronconeumol. 2012 Jul;48(7):247-257. Epub 2012 May 3. English, Spanish.


  30. Donohue JF, Anzueto A, Brooks J, Mehta R, Kalberg C, Crater G.
    A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD.
    Respir Med. 2012 Jul;106(7):970-9. Epub 2012 Apr 10.


  31. Brown MS, Kim HJ, Abtin FG, Strange C, Galperin-Aizenberg M, Pais R, Da Costa IG, Ordookhani A, Chong D, Ni C, McNitt-Gray MF, Tashkin DP, Goldin JG.
    Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes.
    Eur Radiol. 2012 Jul;22(7):1547-55. Epub 2012 Apr 1.


  32. Melani AS. Nebulized corticosteroids in asthma and COPD.
    An Italian appraisal.
    Respir Care. 2012 Jul;57(7):1161-74. Epub 2012 Jan 23. Review.


  33. Kramer MR, Refaely Y, Maimon MN, Rosengarten D, Fruchter O.
    Bilateral Endoscopic Sealant Lung Volume Reduction Therapy for Advanced Emphysema.
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  34. Lammi MR, Panetta N, Vega ME.
    Airway bypass stents for emphysema, algorithm to exclude precapillary pulmonary hypertension, and sildenafil for pulmonary hypertension in heart failure with preserved ejection fraction.
    Am J Respir Crit Care Med. 2012 Jun 15;185(12):1323-4.


  35. Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, López-Campos JL, Soriano JB, Ancochea J.
    [Spanish COPD Guidelines (GesEPOC): Pharmacological treatment of stable COPD.].
    Aten Primaria. 2012 Jun 14. [Epub ahead of print] Spanish.


  36. Destors M, Aniwidyaningsih W, Jankowski A, Pison C.
    Endoscopic volume reduction before or after lung transplantation.
    Eur J Cardiothorac Surg. 2012 Jun 13. [Epub ahead of print].


  37. Ninane V, Geltner C, Bezzi M, Foccoli P, Gottlieb J, Welte T, Seijo L, Zulueta JJ, Munavvar M, Rosell A, Lopez M, Jones PW, Coxson HO, Springmeyer SC, Gonzalez X.
    Multicentre European study for the treatment of advanced emphysema with bronchial valves.
    Eur Respir J. 2012 Jun;39(6):1319-25.


  38. Zhou Y, Tan X, Kuang W, Liu L, Wan L.
    Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats.
    Transl Res. 2012 Jun;159(6):464-72. Epub 2011 Oct 24.


  39. Tanaka K, Sato K, Aoshiba K, Azuma A, Mizushima T.
    Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice.
    Am J Physiol Lung Cell Mol Physiol. 2012 Jun;302(12):L1250-61. Epub 2012 Apr 13.


  40. Lederer DJ, Bartels MN, Schluger NW, Brogan F, Jellen P, Thomashow BM, Kawut SM.
    Sildenafil for chronic obstructive pulmonary disease: a randomized crossover trial.
    COPD. 2012 Jun;9(3):268-75. Epub 2012 Feb 23.


  41. Studart FS, Izbicki M, Nery LE, Oliveira LV, Donner CF, Jardim JR, Nascimento OA.
    Acute and short-term effect of an extra dose of formoterol in COPD patients.
    Respir Med. 2012 Jun;106(6):853-60. Epub 2012 Feb 14.


  42. Herth FJ, Noppen M, Valipour A, Leroy S, Vergnon JM, Ficker JH, Egan JJ, Gasparini S, Agusti C, Holmes-Higgin D, Ernst A; on behalf of the International VENT Study Group.
    Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort.
    Eur Respir J. 2012 Jun;39(6):1334-1342. Epub 2012 Jan 26.


  43. Cruz FF, Antunes MA, Abreu SC, Fujisaki LC, Silva JD, Xisto DG, Maron-Gutierrez T, Ornellas DS, Sá VK, Rocha NN, Capelozzi VL, Morales MM, Rocco PR.
    Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model.
    Respir Physiol Neurobiol. 2012 Jun 15;182(1):26-36. Epub 2012 Jan 13.


  44. Snell G, Herth FJ, Hopkins P, Baker KM, Witt C, Gotfried MH, Valipour A, Wagner M, Stanzel F, Egan JJ, Kesten S, Ernst A.
    Bronchoscopic thermal vapour ablation therapy in the management of heterogeneous emphysema.
    Eur Respir J. 2012 Jun;39(6):1326-33. Epub 2011 Nov 10.


  45. Baldi S, Oliaro A, Tabbia G, Bardessono M, Solidoro P, Mancuso M, Sità C, Ruffini E.
    Lung volume reduction surgery 10 years later.
    J Cardiovasc Surg (Torino). 2012 May 28. [Epub ahead of print]


  46. Vila-Corcoles A, Ochoa-Gondar O, Rodriguez-Blanco T, Gutierrez-Perez A, Vila-Rovira A, Group ES.
    Clinical effectiveness of 23-valent pneumococcal polysaccharide vaccine against pneumonia in patients with chronic pulmonary diseases: A matched case-control study.
    Hum Vaccin Immunother. 2012 May 1;8(5). [Epub ahead of print]


  47. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, Decamp MM, Berger RL.
    An Evidence-Based Estimate on the Size of the Potential Patient Pool for Lung Volume Reduction Surgery.
    Ann Thorac Surg. 2012 May 7. [Epub ahead of print]


  48. Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, López-Campos JL, Soriano JB, Ancochea J.
    Spanish COPD Guidelines (GesEPOC): Pharmacological Treatment of Stable COPD.
    Arch Bronconeumol. 2012 May 3. [Epub ahead of print] English, Spanish.


  49. Herth FJ, Eberhardt R, Gompelmann D, Ficker JH, Wagner M, Ek L, Schmidt B, Slebos DJ.
    Radiological and clinical outcomes of using chartis to plan endobronchial valve treatment.
    Eur Respir J. 2012 May 3. [Epub ahead of print]


  50. Susaki Y, Inoue M, Minami M, Shintani Y, Nakagiri T, Sawabata N, Okumura M.
    Single-lung transplantation in a chronic pulmonary emphysema patient with a marginal donor who was ABO blood group nonidentical but compatible.
    Gen Thorac Cardiovasc Surg. 2012 May;60(5):312-5. Epub 2012 Mar 28.


  51. Melani AS, Canessa P, Coloretti I, DeAngelis G, DeTullio R, Del Donno M, Giacobbe R, Scarlato I, Serafini A, Barbato N, Vaghi A, Sestini P, Educational Study Group of the Italian Association of Hospital Pulmonologists (AIPO).
    Inhaler mishandling is very common in patients with chronic airflow obstruction and long-term home nebuliser use.
    Respir Med. 2012 May;106(5):668-76. Epub 2012 Jan 25.


  52. Wang L, Yang J, Guo L, Uyeminami D, Dong H, Hammock BD, Pinkerton KE.
    Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease.
    Am J Respir Cell Mol Biol. 2012 May;46(5):614-22. Epub 2011 Dec 28.


  53. Venuta F, Anile M, Diso D, Carillo C, De Giacomo T, D'Andrilli A, Fraioli F, Rendina EA, Coloni GF.
    Long-term follow-up after bronchoscopic lung volume reduction in patients with emphysema.
    Eur Respir J. 2012 May;39(5):1084-9. Epub 2011 Oct 17.


  54. Brown MS, Kim HJ, Abtin FG, Strange C, Galperin-Aizenberg M, Pais R, Da Costa IG, Ordookhani A, Chong D, Ni C, McNitt-Gray MF, Tashkin DP, Goldin JG.
    Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes.
    Eur Radiol. 2012 Apr 1. [Epub ahead of print]


  55. Shah PL, Geddes DM.
    Collateral ventilation and selection of techniques for bronchoscopic lung volume reduction.
    Thorax. 2012 Apr;67(4):285-6. Epub 2012 Feb 28.


  56. Magnussen H, Kramer MR, Kirsten AM, Marquette C, Valipour A, Stanzel F, Bonnet R, Behr J, Fruchter O, Refaely Y, Eberhardt R, Herth FJ.
    Effect of fissure integrity on lung volume reduction using a polymer sealant in advanced emphysema.
    Thorax. 2012 Apr;67(4):302-8. Epub 2012 Feb 28.


  57. Kuna P, Jenkins M, O'Brien CD, Fahy WA.
    AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD.
    Respir Med. 2012 Apr;106(4):531-9. Epub 2011 Dec 23.


  58. McGarvey LP, Magder S, Burkhart D, Kesten S, Liu D, Manuel RC, Niewoehner DE.
    Cause-specific mortality adjudication in the UPLIFT® COPD trial: findings and recommendations.
    Respir Med. 2012 Apr;106(4):515-21. Epub 2011 Nov 18


  59. Eberhardt R, Gompelmann D, Schuhmann M, Reinhardt H, Ernst A, Heussel CP, Herth FJ.
    Complete unilateral versus partial bilateral endoscopic lung volume reduction in patients with bilateral lung emphysema.
    Chest. 2012 Mar 29. [Epub ahead of print]


  60. Gompelmann D, Heussel CP, Eberhardt R, Snell G, Hopkins P, Baker K, Witt C, Valipour A, Wagner M, Stanzel F, Egan J, Ernst A, Kesten S, Herth FJ.
    Efficacy of Bronchoscopic Thermal Vapor Ablation and Lobar Fissure Completeness in Patients with Heterogeneous Emphysema.
    Respiration. 2012 Mar 1. [Epub ahead of print]


  61. Jung KS, Park HY, Park SY, Kim SK, Kim YK, Shim JJ, Moon HS, Lee KH, Yoo JH, Lee SD; Korean Academy of Tuberculosis and Respiratory Diseases study group; Korea Chronic Obstructive Pulmonary Disease study group.
    Comparison of tiotropium plus fluticasone propionate/salmeterol with tiotropium in COPD: a randomized controlled study.
    Respir Med. 2012 Mar;106(3):382-9. Epub 2011 Oct 4.


  62. Magnussen H, Kramer MR, Kirsten AM, Marquette C, Valipour A, Stanzel F, Bonnet R, Behr J, Fruchter O, Refaely Y, Eberhardt R, Herth FJ.
    Effect of fissure integrity on lung volume reduction using a polymer sealant* in advanced emphysema.
    Thorax. 2012 Apr;67(4):302-8. Epub 2012 Feb 28.


  63. Le Pimpec-Barthes F, Das Neves-Pereira JC, Cazes A, Arame A, Grima R, Hubsch JP, Zukerman C, Hernigou A, Badia A, Bagan P, Delclaux C, Dusser D, Riquet M.
    Lung volume reduction surgery for emphysema and bullous pulmonary emphysema.
    Rev Pneumol Clin. 2012 Feb 21. French.


  64. Lederer DJ, Bartels MN, Schluger NW, Brogan F, Jellen P, Thomashow BM, Kawut SM.
    Sildenafil for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial.
    COPD. 2012 Feb 23.


  65. Gavaldà A, Gras J, Llupià J, Aubets J, Beleta J, Llenas J.
    Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
    Life Sci. 2012 Feb 13;90(7-8):301-5. Epub 2011 Dec 22. PubMed


  66. Zhang WH, Zhang Y, Cui YY, Rong WF, Cambier C, Devillier P, Bureau F, Advenier C, Gustin P.
    Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD?
    Fundam Clin Pharmacol. 2012 Feb;26(1):118-34. doi: 10.1111/j.1472-8206.2011.01007.x. Epub 2011 Nov 2.


  67. Sharafkhaneh A, Southard JG, Goldman M, Uryniak T, Martin UJ.
    Effect of budesonide/formoterol pMDI on COPD exacerbations: a double-blind, randomized study.
    Respir Med. 2012 Feb;106(2):257-68. Epub 2011 Oct 26.


  68. Podowski M, Calvi C, Metzger S, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, McGrath-Morrow S, Berger A, Cheadle C, Tuder R, Dietz HC, Mitzner W, Wise R, Neptune E.
    Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice.
    J Clin Invest. 2012 Jan 3;122(1):229-40. doi: 10.1172/JCI46215. Epub 2011 Dec 19. PubMed Central PMCID: PMC3248282.


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Rehabilitación pulmonar

  1. Furness T, Bate N, Welsh L, Naughton G, Lorenzen C
    Efficacy of a whole-body vibration intervention to effect exercise tolerance and functional performance of the lower limbs of people with chronic obstructive pulmonary disease
    BMC Pulm Med. 2012 Nov 26;12(1):71


  2. Altenburg WA, de Greef MH, ten Hacken NH, Wempe JB.
    A better response in exercise capacity after pulmonary rehabilitation in more severe COPD patients.
    Respir Med. 2012 May;106(5):694-700. Epub 2011 Dec 6.


  3. Vonbank K, Strasser B, Mondrzyk J, Marzluf BA, Richter B, Losch S, Nell H, Petkov V, Haber P.
    Strength training increases maximum working capacity in patients with COPD--randomized clinical trial comparing three training modalities.
    Respir Med. 2012 Apr;106(4):557-63. Epub 2011 Nov 26.


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EPOC y Cáncer de Pulmón

  1. Kim WJ, Oh YM, Kim TH, Lee JH, Kim EK, Lee JH, Lee SM, Shin TR, Yoon HI, Lim SY, Lee SD
    CHRNA3 Variant for Lung Cancer Is Associated with Chronic Obstructive Pulmonary Disease in Korea
    Respiration. 2012 Nov 27.


  2. Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, Morgenstern H, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Foretova L, Janout V, Bencko V, Schejbalova M, Brennan P, Mates IN, Lazarus P, Field JK, Raji O, McLaughlin JR, Liu G, Wiencke J, Neri M, Ugolini D, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Hung RJ.
    Previous lung diseases and lung cancer risk: a pooled analysis from the international lung cancer consortium.
    Am J Epidemiol. 2012 Oct 1;176(7):573-85. Epub 2012 Sep 17.


  3. Wang H, Yang L, Zou L, Huang D, Guo Y, Pan M, Tan Y, Zhong H, Ji W, Ran P, Zhong N, Lu J.
    Association between Chronic Obstructive Pulmonary Disease and Lung Cancer: A Case-Control Study in Southern Chinese and a Meta-Analysis.
    PLoS One. 2012;7(9):e46144. doi: 10.1371/journal.pone.0046144. Epub 2012 Sep 28. PMCID: PMC3460937.


  4. Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, Morgenstern H, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Foretova L, Janout V, Bencko V, Schejbalova M, Brennan P, Mates IN, Lazarus P, Field JK, Raji O, McLaughlin JR, Liu G, Wiencke J, Neri M, Ugolini D, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Hung RJ.
    Previous lung diseases and lung cancer risk: a pooled analysis from the international lung cancer consortium.
    Am J Epidemiol. 2012 Oct 1;176(7):573-85. Epub 2012 Sep 17.


  5. Ishii T, Hagiwara K, Ikeda S, Arai T, Mieno MN, Kumasaka T, Muramatsu M, Sawabe M, Gemma A, Kida K.
    Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population.
    COPD. 2012 Aug;9(4):409-16. Epub 2012 Apr 18.


  6. Kornum JB, Sværke C, Thomsen RW, Lange P, Sørensen HT.
    Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study.
    Respir Med. 2012 Jun;106(6):845-52. Epub 2012 Jan 2.


  7. Zulueta JJ, Wisnivesky JP, Henschke CI, Yip R, Farooqi AO, McCauley DI, Chen M, Libby DM, Smith JP, Pasmantier MW, Yankelevitz DF.
    Emphysema scores predict death from COPD and lung cancer.
    Chest. 2012 May;141(5):1216-23. Epub 2011 Oct 20.


  8. Ishii T, Hagiwara K, Ikeda S, Arai T, Mieno MN, Kumasaka T, Muramatsu M, Sawabe M, Gemma A, Kida K.
    Association Between Genetic Variations In Surfactant Protein D and Emphysema, Interstitial Pneumonia, and Lung Cancer in a Japanese Population.
    COPD. 2012 Apr 18. [Epub ahead of print]


  9. El-Zein RA, Young RP, Hopkins RJ, Etzel CJ.
    Genetic Predisposition to Chronic Obstructive Pulmonary Disease and/or Lung Cancer: Important Considerations When Evaluating Risk.
    Cancer Prev Res (Phila). 2012 Apr;5(4):522-7.


  10. Smith BM, Schwartzman K, Kovacina B, Taylor J, Kasymjanova G, Brandao G, Agulnik JS.
    Lung cancer histologies associated with emphysema on computed tomography.
    Lung Cancer. 2012 Apr;76(1):61-6. Epub 2011 Sep 25.


  11. Tanimoto D, Ito K, Tamada T, Higaki A, Kanki A, Sato T, Noda Y, Higashi H, Nakata M.
    Serial 3-dimensional volumetric computed tomography evaluation of lung cancer growth rate in patients with chronic obstructive pulmonary disease findings.
    J Comput Assist Tomogr. 2012 Mar;36(2):181-6.


  12. Schroedl C, Kalhan R.
    Incidence, treatment options, and outcomes of lung cancer in patients with chronic obstructive pulmonary disease.
    Curr Opin Pulm Med. 2012 Mar;18(2):131-7. Review.


  13. Mina N, Soubani AO, Cote ML, Suwan T, Wenzlaff AS, Jhajhria S, Samarah H, Schwartz AG.
    The relationship between chronic obstructive pulmonary disease and lung cancer in African American patients.
    Clin Lung Cancer. 2012 Mar;13(2):149-56. Epub 2011 Nov 29.


  14. Palma D, Lagerwaard F, Rodrigues G, Haasbeek C, Senan S.
    Curative treatment of Stage I non-small-cell lung cancer in patients with severe COPD: stereotactic radiotherapy outcomes and systematic review.
    Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1149-56. Epub 2011 Jun 2. Review.


  15. Young RP, Hopkins RJ.
    Chronic obstructive pulmonary disease detection during lung cancer screening.
    JAMA. 2012 Feb 15;307(7):664; author reply 664-5.


  16. Sverzellati N, Cademartiri F, Bravi F, Martini C, Gira FA, Maffei E, Marchianò A, La Vecchia C, De Filippo M, Kuhnigk JM, Rossi C, Pastorino U.
    Relationship and prognostic value of modified coronary artery calcium score, FEV1, and emphysema in lung cancer screening population: the MILD trial.
    Radiology. 2012 Feb;262(2):460-7. Epub 2011 Nov 23.


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Guías y revisiones sistemáticas

  1. Xie X, de Jong PA, Oudkerk M, Wang Y, Ten Hacken NH, Miao J, Zhang G, de Bock GH, Vliegenthart R.
    Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis.
    Eur Radiol. 2012 Oct;22(10):2085-93. doi: 10.1007/s00330-012-2480-8. Epub 2012 Jun 15. PubMed Central PMCID: PMC3431473.


  2. Schou L, Østergaard B, Rasmussen LS, Rydahl-Hansen S, Phanareth K.
    Cognitive dysfunction in patients with chronic obstructive pulmonary disease--a systematic review.
    Respir Med. 2012 Aug;106(8):1071-81. Epub 2012 May 11. Review.


  3. Smith BM, Pinto L, Ezer N, Sverzellati N, Muro S, Schwartzman K.
    Emphysema detected on computed tomography and risk of lung cancer: a systematic review and meta-analysis.
    Lung Cancer. 2012 Jul;77(1):58-63. Epub 2012 Mar 20


  4. Xie X, de Jong PA, Oudkerk M, Wang Y, Ten Hacken NH, Miao J, Zhang G, de Bock GH, Vliegenthart R.
    Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis.
    Eur Radiol. 2012 Jun 15. [Epub ahead of print]


  5. Osadnik CR, McDonald CF, Jones AP, Holland AE.
    Airway clearance techniques for chronic obstructive pulmonary disease.
    Cochrane Database Syst Rev. 2012 Mar 14;3:CD008328.


  6. Smith BM, Pinto L, Ezer N, Sverzellati N, Muro S, Schwartzman K.
    Emphysema detected on computed tomography and risk of lung cancer: A systematic review and meta-analysis.
    Lung Cancer. 2012 Mar 19. [Epub ahead of print]


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